Low-Dose Oral Cyclophosphamide and Methotrexate Maintenance for Hormone Receptor-Negative Early Breast Cancer: International Breast Cancer Study Group Trial 22-00 [Breast Cancer]

Conclusion
CM maintenance did not produce a significant reduction in DFS events in hormone receptor–negative early breast cancer. The trend toward benefit observed in the TN, node-positive subgroup supports additional exploration of this strategy in the TN, higher-risk population.

Source: Journal of Clinical Oncology - September 20, 2016 Category: Cancer & Oncology Authors: Colleoni, Gray, Gelber, Lang, Thurlimann, Gianni, Abdi, Gomez, Linderholm, Puglisi, Tondini, Kralidis, Eniu, Cagossi, Rauch, Chirgwin, Gelber, Regan, Coates, Price, Viale, Goldhirsch Tags: Chemotherapy Breast Cancer Source Type: research