Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis

This study demonstrated that a single intravenous administration of stem cells from human exfoliated deciduous teeth (SHEDs) or of the serum-free conditioned medium (CM) derived from SHEDs markedly improved mouse liver fibrosis (LF). SHED-CM suppressed chronic inflammation, eliminated activated hepatic stellate cells by inducing their apoptosis, protected hepatocytes from undergoing apoptosis, and induced differentiation of tissue-repairing macrophages expressing high levels of the profibrinolytic factor matrix metalloproteinase 13. Furthermore, hepatocyte growth factor played a central role in the SHED-CM-mediated resolution of LF. This is the first report demonstrating the multifaceted therapeutic benefits of secreted factors derived from SHEDs for LF.

Source: Stem Cells Translational Medicine - September 20, 2016 Category: Stem Cells Authors: Hirata, M., Ishigami, M., Matsushita, Y., Ito, T., Hattori, H., Hibi, H., Goto, H., Ueda, M., Yamamoto, A. Tags: Tissue Engineering and Regenerative Medicine, Mesenchymal Stem Cells Source Type: research