MicroRNA-146b, a Sensitive Indicator of Mesenchymal Stem Cell Repair of Acute Renal Injury

In conclusion, elevated miR-146b expression contributes to cisplatin-induced AKI, partly through ErbB4 downregulation. miR-146b might be an early biomarker for AKI, and miR-146b inhibition could be a novel strategy for AKI treatment.

Significance
The present study found that microRNA-146b (miR-146b) might be a novel biomarker for acute kidney injury and an indicator for its recovery after treatment with mesenchymal stem cells (MSCs). The results showed that in acute kidney injury induced by cisplatin, miR-146b in serum increased more quickly than did the usual indexes of kidney injury and decreased with restoration of MSCs. In addition, inhibition of miR-146b could ameliorate the apoptosis induced by cisplatin and potentially improve the proliferation by freeing ErbB4 and its downstream proteins.

Source: Stem Cells Translational Medicine - September 20, 2016 Category: Stem Cells Authors: Zhu, Y., Yu, J., Yin, L., Zhou, Y., Sun, Z., Jia, H., Tao, Y., Liu, W., Zhang, B., Zhang, J., Wang, M., Zhang, X., Yan, Y., Xue, J., Gu, H., Mao, F., Xu, W., Qian, H. Tags: Tissue Engineering and Regenerative Medicine, Adult Stem Cells, Mesenchymal Stem Cells Source Type: research