Influence of Clinical Trial Site Enrollment on Patient Characteristics, Protocol Completion, and End Points: Insights From the ASCEND-HF Trial (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) [Original Article]

Conclusions— In this large, acute heart failure trial, site enrollment correlated with protocol completion and was independently associated with trial end points. Individual and regional site performance present challenges to be considered in design of future acute heart failure trials. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00475852.

http://circheartfailure.ahajournals.org/cgi/content/short/9/9/e002986?rss=1

Source: Circulation: Heart Failure - September 12, 2016 Category: Cardiology Authors: Greene, S. J., Hernandez, A. F., Sun, J.-L., Metra, M., Butler, J., Ambrosy, A. P., Ezekowitz, J. A., Starling, R. C., Teerlink, J. R., Schulte, P. J., Voors, A. A., Armstrong, P. W., OConnor, C. M., Mentz, R. J. Tags: Clinical Studies, Heart Failure, Quality and Outcomes Original Article Source Type: research