Development of a 3D Tissue Culture-Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases

In conclusion, we describe a fully scalable high-content screening platform that uses phenotypic profiling to discriminate selective and nonselective (off-target) inhibitors in a physiologically relevant 3D cell culture setting.

Source: Journal of Biomolecular Screening - September 19, 2016 Category: Molecular Biology Authors: Booij, T. H., Klop, M. J. D., Yan, K., Szantai-Kis, C., Szokol, B., Orfi, L., van de Water, B., Keri, G., Price, L. S. Tags: Special Collection Source Type: research