Next ‐generation sequencing adds value to the preoperative diagnosis of pancreatic cysts

CONCLUSIONSThe detection of KRAS/GNAS variants improves the identification of mucinous neoplasms. Variants in TP53, SMAD4, CDKN2A, and NOTCH1 support the diagnosis of a high‐risk cyst requiring surgery or additional sampling. Although molecular analysis is not a replacement for cytopathology, it does provide valuable information for accurate preoperative diagnosis, helping to classify mucinous neoplasms and high‐risk cysts that require surgical resection. Cancer Cytopathol 2016. © 2016 American Cancer Society.

Source: Cancer Cytopathology - August 31, 2016 Category: Pathology Authors: Matthew W. Rosenbaum, Martin Jones, Jonathan C. Dudley, Long P. Le, A. John Iafrate, Martha B. Pitman Tags: Original Article Source Type: research