Region-specific roles of the corticotropin-releasing factor –urocortin system in stress

Nature Reviews Neuroscience 17, 636 (2016). doi:10.1038/nrn.2016.94 Authors: Marloes J. A. G. Henckens, Jan M. Deussing & Alon Chen Dysregulation of the corticotropin-releasing factor (CRF)–urocortin (UCN) system has been implicated in stress-related psychopathologies such as depression and anxiety. It has been proposed that CRF–CRF receptor type 1 (CRFR1) signalling promotes the stress response and anxiety-like behaviour, whereas UCNs and CRFR2 activation mediate stress recovery
Source: Nature Reviews Neuroscience - Category: Neuroscience Authors: Tags: Review Source Type: research