Abrogated cardio protective effect of ischemic preconditioning in hyperhomocysteinemia and hypertrophy

Publication date: Available online 1 July 2016 Source:Journal of Indian College of Cardiology Author(s): Shaiba Sana Qureshi, Ahsas Goyal Coronary heart disease has almost affected the mankind throughout history. During the last century, this disorder has emerged as a leading cause of death all over the world. Ischemia contributes in the development of myocardial infarction, stroke, peripheral vascular insufficiency and hypovolemic shock. Reperfusion enhances the tissue injury produced by ischemia alone. Cellular damage after reperfusion of formerly viable ischemic tissues is known as ischemia–reperfusion (I–R) injury. Ischemic preconditioning is known as the phenomenon in which the short intermittent cycles of ischemia and reperfusion has shown to improve myocardium against subsequent prolonged ischemia–reperfusion (I–R)induced injury. Experimentally, preconditioning has revealed to improve ventricular function and to decrease apoptosis and myocardial neutrophil accumulation after ischemia reperfusion injury. Recently, ischemic preconditioning has been demonstrated to have a beneficial effect on recovery of right ventricular contractility in coronary artery bypass grafting and to improve liver injury during hepatic resection. The cardioprotective role of ischemic preconditioning is well established, but it is lost in various clinical conditions such as hyperhomocysteinemia and cardiac hypertrophy. In this review, we have discussed the various signaling pathways w...
Source: Journal of Indian College of Cardiology - Category: Cardiology Source Type: research