Endocrine therapy and strategies to overcome therapeutic resistance in breast Cancer

Despite the remarkable success of endocrine therapy in the treatment of patients with Estrogen Receptor (ER) positive breast cancer, not all patients derive benefit from such therapy, or may benefit only temporarily before disease progression or relapse occurs. The value of endocrine therapy, which blocks ER signaling by a variety of strategies, lies in its simplicity, lower toxicity, and better alignment with preserved quality of life, particularly when compared to chemotherapy, which is more toxic and has only modest benefits for many patients with ER-positive breast cancer.
Source: Current Problems in Cancer - Category: Cancer & Oncology Authors: Source Type: research