Association between XRCC3 Thr241Met polymorphism and nasopharyngeal carcinoma risk: evidence from a large-scale case-control study and a meta-analysis

AbstractThe X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism (rs861539, C  >  T) has drawn wide attentions as its association with cancer risk and its involvement in DNA repair. Several studies have attempted to link rs861539 to nasopharyngeal cancer (NPC) risk; however, the sample sizes of these studies are small and the results are controversial. To investigate the relati onship of rs861539 and NPC susceptibility, we conducted a large-scale case-control study involving 4001 NPC cases and 2967 controls of southern Chinese. Logistic regression analysis revealed significant association for rs861539 and NPC risk under the recessive model (TT vs. CT + CC) with adjustmen t of age and gender (odds ratio,OR =  2.72; 95 % CI 1.10–6.72;P = 0.03). Further, meta-analysis involving 4457 NPC cases and 4132 controls from four studies showed consistent association of TT carriers and NPC risk (OR = 3.12; 95 % CI 1.58–6.13;P = 0.001). Taken together, our findings based on large-scale sample size suggested rs861539 atXRCC3 to be associated with NPC risk through recessive model.
Source: Tumor Biology - Category: Cancer & Oncology Source Type: research