Overexpression of angiotensinogen downregulates aquaporin 1 expression via modulation of Nrf2-HO-1 pathway in renal proximal tubular cells of transgenic mice

Conclusions:
Angiotensinogen-mediated downregulation of aquaporin 1 and Nrf2 signalling may play an important role in intrarenal renin–angiotensin system-induced hypertension and kidney injury.

Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - September 14, 2016 Category: Biomedical Science Authors: Chang, S.-Y., Lo, C.-S., Zhao, X.-P., Liao, M.-C., Chenier, I., Bouley, R., Ingelfinger, J. R., Chan, J. S., Zhang, S.-L. Tags: Original Article Source Type: research