Cytology smears as excellent starting material for next ‐generation sequencing‐based molecular testing of patients with adenocarcinoma of the lung

CONCLUSIONSThe results of the current study demonstrated the suitability of non‐formalin cytology specimens for the simultaneous NGS testing of lung ADCs using amplicon resequencing panels. These assays allowed for the input of cytological smears equal to concurrent histology or cell blocks and proved to be accurate in the detection of therapeutically actionable somatic mutations and gene rearrangements. Cancer Cytopathol 2016. © 2016 American Cancer Society.

Source: Cancer Cytopathology - September 15, 2016 Category: Pathology Authors: Nadezda P. Velizheva, Markus P. Rechsteiner, Christine E. Wong, Qing Zhong, Matthias R össle, Beata Bode, Holger Moch, Alex Soltermann, Peter J. Wild, Verena Tischler Tags: Original Article Source Type: research