Differences in Accumulation and the Transport Mechanism of l- and d-Methionine in High- and Low-Grade Human Glioma Cells

Although [S-methyl-11C]-labeled L- and D-methionine (11C-L- and D-MET) are useful radiotracers for positron emission tomography imaging of brain tumors, it is not known whether the accumulation and transport mechanisms underlying uptake of 11C-D-MET and 11C-L-MET are the same. 11C-L-MET is mainly taken up by the amino acid transport system L. We evaluated accumulation and the transport mechanism of D-MET in high- and low-grade human glioma cells in vitro.

Source: Nuclear Medicine and Biology - September 13, 2016 Category: Nuclear Medicine Authors: Masato Kobayashi, Asuka Mizutani, Kodai Nishi, Syuichi Nakajima, Naoto Shikano, Ryuichi Nishii, Kazuki Fukuchi, Keiichi Kawai Source Type: research