Liver transplantation in transthyretin amyloidosis: characteristics and management related to kidney disease

Orthotopic liver transplantation (LT) was implemented as the inaugural disease-modifying therapy for hereditary transthyretin (ATTR) amyloidosis, a systemic amyloidosis mainly affecting the peripheral nervous system and heart. The first approach to pharmacologic therapy was focused on the stabilization of the TTR tetramer; following that new advent LT was assumed as the second step of treatment, for those patients whose neuropathy becomes worse after a course of pharmacologic therapy.The renal disease has been ignored in hereditary ATTR amyloidosis.
Source: Transplantation Reviews - Category: Transplant Surgery Authors: Source Type: research