Intermittent Cyclic Mechanical Tension Promotes Degeneration of Endplate Cartilage via the Nuclear Factor ‐κB Signaling Pathway: an in Vivo Study

ConclusionThese experiments indicate that ICMT contributes to the activation of NF‐κB signaling pathway in vivo and that the NF‐κB signaling pathway further up‐regulates MMP13, leading to degeneration of endplate cartilage.

Source: Orthopaedic Surgery - September 13, 2016 Category: Orthopaedics Authors: Liang Xiao, Hong ‐guang Xu, Hong Wang, Ping Liu, Chen Liu, Xiang Shen, Tao Zhang, Yong‐ming Xu Tags: SCIENTIFIC ARTICLE Source Type: research