The fruit of Acanthopanax senticosus (Rupr. et Maxim) Harms improves insulin resistance and hepatic lipid accumulation by modulation of liver AMP-activated protein kinase activity and lipogenic gene expression in high-fat-diet-fed obese mice

Obesity-associated insulin resistance is a major risk factor for most metabolic diseases, including dyslipidemia and type 2 diabetes. Acanthopanax senticosus (Rupr. et Maxim) Harms (Goka) root has been used in traditional Chinese Medicine for treatment of diabetes and other conditions; however, little is known about the effects of Goka fruit (GF). GF is rich in anthocyanin, which has beneficial effects on obesity and insulin resistance via activation of AMP-activated protein kinase (AMPK). We hypothesized that GF can improve obesity-associated insulin resistance.
Source: Nutrition Research - Category: Nutrition Authors: Tags: Original Research Source Type: research