Di(2 ‐ethylhexyl)phthalate: Adverse effects on folliculogenesis that cannot be neglected

This article reviews the evidence, with particular reference to our own findings, that DEHP may actually exert a variety of adverse effects on mammalian folliculogenesis from early to final stages of oogenesis, including altered development of the primordial germ cells, impaired fetal oocyte survival and meiotic progression, reduced oocyte nest breakdown, acceleration of primordial follicle activation, altered follicle steroidogenesis and increased follicle atresia. These effects can cause serious complications for reproductive and nonreproductive women's health. In addition, emerging data indicate that phthalates, including DEHP, may cause subtle epigenetic changes in germ cells that can be transmitted to subsequent generations, with potential negative effects on human health. Environ. Mol. Mutagen., 2016. © 2016 Wiley Periodicals, Inc.

Source: Environmental and Molecular Mutagenesis - August 16, 2016 Category: Molecular Biology Authors: Teng Zhang, Wei Shen, Massimo De Felici, Xi ‐Feng Zhang Tags: Review Source Type: research