Inhibition of viability of microorganisms in [18F]-labelled radiopharmaceuticals

Good Manufacturing Practice (GMP)-compliant production of radiopharmaceuticals for parenteral application requires great efforts in maintenance of clean room infrastructure and equipment in order to reliably guarantee the constant hygienic quality of the product (sterility). Terminal sterilisation of the product is not always possible due to short half-life or due to thermal instability of the compound. The typical method for sterilisation in these cases is sterile filtration prior to dispensing (distribution of product solution from bulk to patient vials).
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research