Amyloid-{beta} Precursor Protein Modulates the Sorting of Testican-1 and Contributes to Its Accumulation in Brain Tissue and Cerebrospinal Fluid from Patients with Alzheimer Disease

In conclusion, patient data reflect a clearance impairment that may favor Aβ accumulation in AD brains and our in vitro model supports the notion that the interaction between APP and Testican-1 may be a key step in the production and aggregation of Aβ species.

Source: Journal of Neuropathology and Experimental Neurology - September 7, 2016 Category: Neurology Authors: Barrera-Ocampo, A., Arlt, S., Matschke, J., Hartmann, U., Puig, B., Ferrer, I., Zürbig, P., Glatzel, M., Sepulveda-Falla, D., Jahn, H. Tags: Original Articles Source Type: research