Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model

Conclusions: Resistance to TAM may be preprogrammed by in utero exposure to high estrogen levels and mediated through reversible epigenetic alterations in genes associated with epithelial-mesenchymal transition and tumor immune responses.

Source: JNCI - September 7, 2016 Category: Cancer & Oncology Authors: Hilakivi-Clarke, L., Wärri, A., Bouker, K. B., Zhang, X., Cook, K. L., Jin, L., Zwart, A., Nguyen, N., Hu, R., Cruz, M. I., de Assis, S., Wang, X., Xuan, J., Wang, Y., Wehrenberg, B., Clarke, R. Tags: Article Source Type: research