Colon cancer in hereditary syndromes

Though representing less than 10% of colorectal cancers diagnosed worldwide, inherited colon cancer syndromes are important as their identification allows for screening and early interventions for both patients and their potentially affected family members. Both autosomal dominant and recessive gene mutations have been linked with these syndromes. High penetrance mutations, such as those involved in tumor suppression or mismatch repair mechanisms, lead to phenotypes with increased colorectal cancer risk.

Source: Seminars in Colon and Rectal Surgery - April 24, 2016 Category: Gastroenterology Authors: Alexander T. Hawkins, Paul E. Wise Source Type: research