Valproic acid as an antiepileptic drug: Is there a clinical relevance for the epilepsy surgeon?

VPA induced coagulopathy is a major concern for epilepsy surgeons despite patients having a normal blood coagulation profile (Gallais et al., 1996; Teich et al., 2004; Unalp et al., 2008). However, quite a few significant VPA coagulopathy associated hemorrhagic complications have been reported (Kumar, 2005; Raghuveer et al., 1989). Few anecdotal reports of difficult hemostasis during surgery and post-operative bleeding episodes requiring evacuation of clots in patients on VPA therapy are available in literature (Cannizzaro et al., 2007; Pohlmann-Eden et al., 2003).

Source: Epilepsy Research - September 3, 2016 Category: Neurology Authors: Nilesh Kurwale, Kanwaljeet Garg, Amit Arora, Poodipedi Sarat Chandra, Manjari Tripathi Tags: Short communication Source Type: research