How Eye-Preserving Therapy Affects Long-Term Overall Survival in Heritable Retinoblastoma Survivors [Pediatric Oncology]

Conclusion The benefits of preserving vision must be balanced with the impact of eye-preserving treatments on long-term survival in heritable retinoblastoma, and the genetic background of the patient influences choice of eye-preserving treatment. Germline RB1 genetic analysis is important to identify heritable retinoblastoma among unilateral retinoblastoma cases. Eye-preserving radiotherapy should be carefully considered in patients with germline RB1 mutations. Life-long oncologic follow-up is crucial for all retinoblastoma survivors, and less detrimental eye-preserving therapies must be developed.
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Genetic epidemiology, Population and observational studies (SEER, WHI observational, etc.), Radiation, Chemotherapy, Retinoblastoma, Epidemiology, Osteosarcoma, Retinoblastoma, Rhabdomyosarcoma & Soft Tissue Sarcoma, Long Term Survival & Late Effects, Rad Source Type: research