Concomitant multiple sclerosis and another autoimmune disease: Does the clinical course change?

Multiple Sclerosis (MS) is a chronic demyelinating disease of the nervous system that may cause various signs and symptoms by autoimmune involvement of the brain and spinal cord [1]. The disease has both inflammatory and neurodegenerative nature which complicates understanding its etiology and pathophysiology [2]. Myelin destruction, inflammation and axonal loss are prominent pathological hallmark of the disease [3]. BothCD4+ and CD8+ T-cells as well as B-lymphocytes are involved in this inflammatory process and mediate tissue injury to the central nervous system [4,5].

Source: Clinical Neurology and Neurosurgery - September 2, 2016 Category: Neurosurgery Authors: Mohammad Ali Sahraian, Mahsa Owji, Abdorreza Naser Moghadasi Source Type: research