Involvement of NADPH oxidase and NF- κB activation in CXCL1 induction by vascular endothelial growth factor in human endometrial epithelial cells of patients with adenomyosis

Chemokines are a group of small heparin-binding proteins that can be divided into four subfamilies. Among these, CXC chemokines are defined by the arrangement of the first two of four invariant cysteine residues found in most chemokines and are further subgrouped according to the presence or absence of a three amino acid ‘ELR’ (Glu-Leu-Arg) motif preceding the CXC sequence. The CXCL1 belongs to CXC chemokines, which can bind to CXCR2 chemokine receptor and induce chemotaxis of circulating leukocytes to the sites of inflammation (Charo and Ransohoff, 2006).

Source: Journal of Reproductive Immunology - September 1, 2016 Category: Allergy & Immunology Authors: Tsung-Hsuan Lai, Pi-Hui Wu, Wen-Bin Wu Source Type: research