Tactics for preclinical validation of receptor-binding radiotracers

Aspects of radiopharmaceutical development are illustrated through preclinical studies of [125I]-(E)-1-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-4-(iodoallyl)piperazine ([125I]-E-IA-BF-PE-PIPZE), a radioligand for sigma-1 ( σ1) receptors, coupled with examples from the recent literature. Findings are compared to those previously observed for [125I]-(E)-1-(2-(2,3-dimethoxy-5-yl)ethyl)-4-(iodoallyl)piperazine ([125I]-E-IA-DM-PE-PIPZE).

Source: Nuclear Medicine and Biology - September 1, 2016 Category: Nuclear Medicine Authors: Susan Z. Lever, Kuo-Hsien Fan, John R. Lever Source Type: research