Extended versus standard azathioprine maintenance therapy in newly diagnosed proteinase-3 anti-neutrophil cytoplasmic antibody-associated vasculitis patients who remain cytoplasmic anti-neutrophil cytoplasmic antibody-positive after induction of remission: a randomized clinical trial

Conclusions
This randomized trial suggests that extended azathioprine maintenance therapy has only a limited effect on the prevention of relapse in patients with PR3-AAV at 4 years after diagnosis. Moreover, positive C-ANCA status at stable remission was not associated with an increased rate of relapse.

Trial registration
ClinicalTrials.gov NCT 00128895.

Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Sanders, J.-S. F., de Joode, A. A. E., DeSevaux, R. G., Broekroelofs, J., Voskuyl, A. E., van Paassen, P., Kallenberg, C. G. M., Tervaert, J. W. C., Stegeman, C. A. Tags: Acute Kidney Injury Source Type: research