The Intracellular Effect of Relaxin on Female Anterior Cruciate Ligament Cells
Conclusion:
Relaxin-2 significantly upregulated intracellular processes in human female ACL cells, but no effect was observed in male cells. Relaxin increased MMP (MMP1 and MMP3) and decreased αSMA and type I and III collagen expression, which may act to alter the structural integrity of the ACL tissue over time.
Clinical Relevance:
Female athletes with higher circulating relaxin levels may be more susceptible to ACL injury.
Source: The American Journal of Sports Medicine - Category: Sports Medicine Authors: Konopka, J. A., DeBaun, M. R., Chang, W., Dragoo, J. L. Tags: Knee ligaments, ACL, Female athlete Source Type: research