Biologically inspired survival analysis based on integrating gene expression as mediator with genomic variants

Accurately linking cancer molecular profiling with survival can lead to improvements in the clinical management of cancer. However, existing survival analysis relies on statistical evidence from a single level of data, without paying much attention to the integration of interacting multi-level data and the underlying biology. Advances in genomic techniques provide unprecedented power of characterizing the cancer tissue in a more complete manner than before, offering the opportunity to design biologically informed and integrative approaches for survival data analysis.
Source: Computers in Biology and Medicine - Category: Bioinformatics Authors: Source Type: research