A simple yet accurate correction for winner's curse can predict signals discovered in much larger genome scans

Conclusions: FIQT is a simple, yet accurate, WCA method for Z-scores (and ORs/RRs, via simple transformations). Availability and Implementation: A 10 lines R function implementation is available at https://github.com/bacanusa/FIQT. Contact: sabacanu@vcu.edu Supplementary information: Supplementary data are available at Bioinformatics online.

http://bioinformatics.oxfordjournals.org/cgi/content/short/32/17/2598?rss=1

Source: Bioinformatics - August 31, 2016 Category: Bioinformatics Authors: Bigdeli, T. B., Lee, D., Webb, B. T., Riley, B. P., Vladimirov, V. I., Fanous, A. H., Kendler, K. S., Bacanu, S.-A. Tags: GENOME ANALYSIS Source Type: research