L1 regularization facilitates detection of cell type-specific parameters in dynamical systems

In conclusion, the approach constitutes a general method to infer an overarching model with a minimum number of individual parameters for the particular models. Availability and Implementation: A MATLAB implementation is provided within the freely available, open-source modeling environment Data2Dynamics. Source code for all examples is provided online at http://www.data2dynamics.org/. Contact: bernhard.steiert@fdm.uni-freiburg.de

http://bioinformatics.oxfordjournals.org/cgi/content/short/32/17/i718?rss=1

Source: Bioinformatics - August 31, 2016 Category: Bioinformatics Authors: Steiert, B., Timmer, J., Kreutz, C. Tags: SYSTEMS Source Type: research

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