Test for association of common variants in GRM7 with alcohol consumption

Recent work using a mouse model has identified the glutamate metabotropic receptor 7 (Grm7) gene as a strong candidate gene for alcohol consumption. Although there has been some work examining the effect of human glutamate metabotropic receptor 7 (GRM7) polymorphisms on human substance use disorders, the majority of the work has focused on other psychiatric disorders such as ADHD, major depressive disorder, schizophrenia, bipolar disorder, panic disorder, and autism spectrum disorders. The current study aimed to evaluate evidence for association between GRM7 and alcohol behaviors in humans using a single nucleotide polymorphism (SNP) approach, as well as a gene-based approach.

Source: Alcohol - August 30, 2016 Category: Addiction Authors: Whitney E. Melroy-Greif, Csaba Vadasz, Helen M. Kamens, Matthew B. McQueen, Robin P. Corley, Michael C. Stallings, Christian J. Hopfer, Kenneth S. Krauter, Sandra A. Brown, John K. Hewitt, Marissa A. Ehringer Source Type: research