Patients with Obstructive Sleep Apnea Have Cardiac Repolarization Disturbances when Travelling to Altitude: Randomized, Placebo-Controlled Trial of Acetazolamide

Conclusions:At 2590 m OSA patients experienced cardiac repolarization disturbances in association with hypoxemia. Prolongation of meanQTc at altitude was prevented and hypoxemia was improved by acetazolamide, whereas maxQTc remained increased suggesting imperfect protection from repolarization disturbances.Clinical Trial Registration:ClinicalTrials.gov ID: NTC-00714740. URL:www.clinicaltrials.govCitation:Latshang TD, Kaufmann B, Nussbaumer-Ochsner Y, Ulrich S, Furian M, Kohler M, Thurnheer R, Saguner AM, Duru F, Bloch KE. Patients with obstructive sleep apnea have cardiac repolarization disturbances when travelling to altitude: randomized, placebo-controlled trial of acetazolamide.SLEEP 2016;39(9):1631–1637.
Source: Sleep - Category: Sleep Medicine Source Type: research