A miRNA target network putatively involved in follicular atresia

In a previous microarray study, we identified a subset of micro RNAS (miRNAs), which expression was distinctly higher in atretic than healthy follicles of cattle. In the present study, we investigated the involvement of those miRNAs in granulosa and theca cells during atresia. RT-qPCR confirmed that miR-21-5p/-3p, miR-150, miR-409a, miR-142-5p, miR-378, miR-222, miR-155, and miR-199a-5p were expressed at higher levels in atretic than healthy follicles (9 –17 mm, classified based on steroidogenic capacity).

Source: Domestic Animal Endocrinology - August 12, 2016 Category: Endocrinology Authors: F.X. Donadeu, J. Ioannidis Source Type: research