Renal Amyloidosis

Amyloidosis is a rare disease caused by extracellular deposition of proteins in an insoluble beta-pleated physical conformation. Multiple causative proteins have been identified in amyloidosis, all leading to a similar alteration in structural change leading to extracellular deposition of fibrils. The kidney is a common site of amyloid deposition in AL, AA and the hereditary amyloidosis. Amyloid kidney can be difficult to recognize because of its subtle presentation and insidious progression. In fact, most cases of amyloidosis are diagnosed after recognition of multi-organ dysfunction, including: heart failure, renal insufficiency associated with proteinuria, autonomic dysregulation, and neuropathy.
Source: Current Problems in Cancer - Category: Cancer & Oncology Authors: Tags: Amyloidosis and its management Source Type: research