Comparative evaluation of 4 and 6-carbon spacer conformationally flexible tetrahydroisoquinolinyl benzamide analogues for imaging the sigma-2 receptor status of solid tumors

Nine novel analogues were synthesized including a 6-carbon spacer analogue of ISO-1 (7). They have moderate binding affinity for sigma-2 ( σ2) receptors and high selectivity for σ2 receptors relative to sigma-1 (σ1) receptors.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research