Monooxorhenium(V) complexes with 222-N2S2 MAMA ligands for bifunctional chelator agents: Syntheses and preliminary in vivo evaluation

Targeted radiotherapy using the bifunctional chelate approach with 186/188Re(V) is challenging because of the susceptibility of monooxorhenium(V)-based complexes to oxidize in vivo at high dilution. A monoamine-monoamide dithiol (MAMA)-based bifunctional chelating agent was evaluated with both rhenium and technetium to determine its utility for in vivo applications.

Source: Nuclear Medicine and Biology - August 29, 2016 Category: Nuclear Medicine Authors: Dustin Wayne Demoin, Ashley N. Dame, William D. Minard, Fabio Gallazzi, Gary L. Seickman, Tammy L. Rold, Nicole Bernskoetter, Michael E. Fassbender, Timothy J. Hoffman, Carol A. Deakyne, Silvia S. Jurisson Source Type: research