Cerebral Glucose Metabolism and Dopaminergic Function in Patients with Corticobasal Syndrome

CONCLUSIONSWe replicated and refined earlier findings of impaired glucose metabolism and nigrostriatal degeneration in CBS, highlighting asymmetric cortical and subcortical hypometabolism, symmetrically reduced metabolism in the thalamus, and only a slightly asymmetric reduction in DAT, while D2/3 receptors seem to be mainly preserved. These results provide systematic evidence for the usefulness of FDG PET and dopaminergic SPECT imaging to characterize CBS.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fjon.12391

Source: Journal of Neuroimaging - August 30, 2016 Category: Radiology Authors: Erik Mille, Johannes Levin, Matthias Brendel, Christian Zach, Henryk Barthel, Osama Sabri, Kai B ötzel, Peter Bartenstein, Adrian Danek, Axel Rominger Tags: Clinical Investigative Study Source Type: research