The persistent dynamic secrets of senescence

Nature Cell Biology 18, 913 (2016). doi:10.1038/ncb3403 Author: Clemens A. Schmitt While the beneficial versus detrimental implications of the senescence-associated secretome remain an issue of debate, time-resolved analyses of its composition, regulatory mechanisms and functional consequences have been largely missing. The dynamic activity of NOTCH is now shown to direct two distinct senescence phenotypes, by first promoting a pro-senescent TGF-β1-dependent secretome, followed by a second wave of pro-inflammatory, senescence-clearing cytokines.

http://feeds.nature.com/~r/ncb/rss/current/~3/uqZO1tuoCac/ncb3403

Source: Nature Cell Biology - August 29, 2016 Category: Cytology Authors: Clemens A. Schmitt Tags: News and Views Source Type: research

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