Adjusted inference procedures for the interobserver agreement in twin studies

We propose adjusted inference procedures for evaluating the agreement/disagreement of two raters in a clustered setting involving twins or paired body parts. These procedures include the construction of a confidence interval for the kappa statistic, a related test of statistical significance and a formula that facilitates sample size estimation. The results of a simulation study suggest that a simple adjustment using an estimated design effect will provide valid inferences. The methods proposed are illustrated using an example from the literature.

Source: Statistical Methods in Medical Research - August 25, 2016 Category: Statistics Authors: Dixon, S. N., Donner, A., Shoukri, M. M. Tags: Regular Articles Source Type: research