Daily sesame oil supplementation mitigates ketoconazole-induced oxidative stress-mediated apoptosis and hepatic injury

Ketoconazole (KCZ) is the most commonly used systemic antifungal drug. However, long-term treatment of KCZ induces hepatic injury. Oxidative stress is involved in KCZ-induced hepatic injury. Oxidative stress plays an important role in apoptosis-associated hepatic damage. Sesame oil is rich in potent antioxidants and antifungal constituents. It attenuates hepatic injury by inhibiting oxidative stress. Thus, sesame oil may protect against KCZ-induced oxidative stress, apoptosis, and hepatic damage.

Source: The Journal of Nutritional Biochemistry - August 24, 2016 Category: Biochemistry Authors: Srinivasan Periasamy, Chuan-Teng Liu, Se-Ping Chien, Ying-Chien Chen, Ming-Yie Liu Source Type: research