Ala5-galanin (2 –11) is a GAL2R specific galanin analogue

It is over 30years since the regulatory peptide galanin was discovered by Professor Mutt and co-workers. Galanin exerts its effects by binding to three galanin G-protein coupled receptors, namely GAL1R, GAL2R and GAL3R. Each galanin receptor has a different distribution in the central nervous system and the peripheral nervous system as well as distinctive signaling pathways, which implicates that the receptors are involved in different biological- and pathological effects. The delineation of the galaninergic system is however difficult due to a lack of stable, specific galanin receptor ligands.

Source: Neuropeptides - August 23, 2016 Category: Neuroscience Authors: Kristin Webling, Johan Runesson, Andreas Lang, Indrek Saar, Barbara Kofler, Ülo Langel Source Type: research