Integrating Evolutionary Game Theory into an Agent-Based Model of Ductal Carcinoma in Situ: Role of Gap Junctions in Cancer Progression

• The propagation of signals via gap junctions is modeled by using evolutionary game theory.• Game theory payoffs are considered to be a function of cellular context.• The results show the gap junction communication reduces cancer progression.• The model illustrates the role of gap junctions at the early stage of cancer.

Source: Computer Methods and Programs in Biomedicine - August 23, 2016 Category: Bioinformatics Authors: Negin Malekian, Jafar Habibi, Mohammad Hossein Zangooei, Hojjat Aghakhani Source Type: research