The CXCL8-CXCR1/2 pathways in cancer

Long-lasting chronic infection is a hallmark of tumourigenesis. Inflammation caused by chemical and physical agents increases the risk of malignancy [1]. Inflammatory responses to numerous cytokines in the tumour microenvironment play a more crucial role in facilitating tumour growth, progression, and immunosuppression compared to rendering a potent anti-tumour effect [2].

Source: Cytokine and Growth Factor Reviews - August 23, 2016 Category: Molecular Biology Authors: Qian Liu, Anping Li, Yijun Tian, Jennifer D. Wu, Yu Liu, Tengfei Li, Yuan Chen, Xinwei Han, Kongming Wu Source Type: research