DNA Mismatch Repair Deficiency in Rectal Cancer: Benchmarking Its Impact on Prognosis, Neoadjuvant Response Prediction, and Clinical Cancer Genetics [Gastrointestinal Cancer]

Conclusion dMMR rectal cancer had excellent prognosis and pathologic response with current multimodality therapy including an individualized surgical treatment plan. Identification of a dMMR rectal cancer should trigger germline testing, followed by lifelong surveillance for both colorectal and extracolorectal malignancies. We herein provide genotype-specific outcome benchmarks for comparison with novel interventions.

http://jco.ascopubs.org/cgi/content/short/34/25/3039?rss=1

Source: Journal of Clinical Oncology - August 23, 2016 Category: Cancer & Oncology Authors: de Rosa, Rodriguez-Bigas, Chang, Veerapong, Borras, Krishnan, Bednarski, Messick, Skibber, Feig, Lynch, Vilar, You Tags: Surgery, Combined Modality, Translational Oncology, Surgical Oncology Gastrointestinal Cancer Source Type: research