Preischemic Administration of Nonexpanded Adipose Stromal Vascular Fraction Attenuates Acute Renal Ischemia/Reperfusion Injury and Fibrosis

In conclusion, our study demonstrated that preischemic administration of nonexpanded adipose SVF protected the kidney from both acute IR injury and long-term risk of developing CKD. Significance Renal ischemia/reperfusion (IR) injury is a common clinical syndrome. Cell-based therapy provides a promising option to promote renal repair after IR injury. However, several challenges still remain because of the potential risks during cell culture, low retention rate after transplantation, and unclear effect on the progression of chronic kidney disease. Stromal vascular fraction (SVF) is considered as an attractive cell source. This study demonstrated that preischemic administration of uncultured SVF could increase cell retention and then improve renal function and structure at both early and long-term stage after IR, which may provide a novel therapeutic approach for IR injury.

http://stemcellstm.alphamedpress.org/cgi/content/short/5/9/1277?rss=1

Source: Stem Cells Translational Medicine - August 23, 2016 Category: Stem Cells Authors: Zhou, L., Xu, L., Shen, J., Song, Q., Wu, R., Ge, Y., Xin, H., Zhu, J., Wu, J., Jia, R. Tags: Tissue Engineering and Regenerative Medicine, Adipose-Derived Stem Cells Source Type: research