Adipose-Derived Mesenchymal Stem Cells Ameliorate Lipid Metabolic Disturbance in Mice

This study demonstrated that adipose-derived MSCs (AD-MSCs) infusion can significantly suppress the increase in body weight and remarkably improve dyslipidemia in obese mice. Induction of white fat tissue "browning" and activation of adenosine monophosphate-activated protein kinase and its downstream hormone-sensitive lipase in adipose tissue were demonstrated to contribute to the antiobesity and lipid-lowering effects. Thus, AD-MSC infusion holds great therapeutic potential for dyslipidemia.

Source: Stem Cells Translational Medicine - August 23, 2016 Category: Stem Cells Authors: Liu, G.-Y., Liu, J., Wang, Y.-L., Liu, Y., Shao, Y., Han, Y., Qin, Y.-R., Xiao, F.-J., Li, P.-F., Zhao, L.-J., Gu, E.-Y., Chen, S.-Y., Gao, L.-H., Wu, C.-T., Hu, X.-W., Duan, H.-F. Tags: Adipose-Derived Stem Cells, Tissue-Specific Progenitor and Stem Cells Source Type: research