De Novo Discovery of Structured ncRNA Motifs in Genomic Sequences
De novo discovery of “motifs” capturing the commonalities among related noncoding
ncRNA
structured RNAs is among the most difficult problems in computational biology. This chapter outlines the challenges presented by this problem, together with some approaches towards solving them, with an emphasis on an approach based on the CMfinder
CMfinder
program as a case study. Applications to genomic screens for novel de novo structured ncRNA
ncRNA
s, including structured RNA elements in untranslated portions of protein-coding genes, are presented.
Source: Springer protocols feed by Bioinformatics - Category: Bioinformatics Source Type: news