On the Statistics of Identifying Candidate Pathogen Effectors

High-throughput sequencing is an increasingly accessible tool for cataloging gene complements of plant pathogens and their hosts. It has had great impact in plant pathology, enabling rapid acquisition of data for a wide range of pathogens and hosts, leading to the selection of novel candidate effector proteins, and/or associated host targets (Bart et al., Proc Nat Acad Sci U S A doi:10.1073/pnas.1208003109, 2012; Agbor and McCormick, Cell Microbiol 13:1858–1869, 2011; Fabro et al., PLoS Pathog 7:e1002348, 2011; Kim et al., Mol Plant Pathol 2:715–730, 2011; Kimbrel et al., Mol Plant Pathol 12:580–594, 2011; O’Brien et al., Curr Opin Microbiol 14:24–30, 2011; Vleeshouwers et al., Annu Rev Phytopathol 49:507–531, 2011; Sarris et al., Mol Plant Pathol 11:795–804, 2010; Boch and Bonas, Annu Rev Phytopathol 48:419–436, 2010; Mcdermott et al., Infect Immun 79:23–32, 2011).
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