Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes

Conclusions: The agonistic effects on the mAChRs (particularly M1 subtype, and also probably M4 subtype), the 5-HT1A receptor and the -opioid receptor expressed in native brain tissues, some of which are common to both compounds and others specific to either, likely shape the unique beneficial effectiveness of both compounds in the treatment for schizophrenic patients. These characteristics provide us with a clue to develop newer antipsychotics, beyond the framework of dopamine D2 receptor antagonism, that are effective not only on positive symptoms but also on negative symptoms and/or cognitive/affective impairment.
Source: Journal of Psychopharmacology - Category: Psychiatry Authors: Tags: Original Papers Source Type: research